Investigating Matrix Interference in Analysis of Antiarrhythmic Cardiac Drugs in Plasma

Introduction

For efficient therapeutic drug monitoring, it is important for clinicians to have access to fast and robust analytical methods for accurate assessment of drug efficacy. Industrial trends toward highly specific LC/MS applications over traditional immunoassay have resulted in the need for high-speed chromatographic assays along with simplified sample preparation methods. Often the limitation of a bioanalytical technique is based upon the effectiveness of the sample preparation technique. Plasma and serum samples are often susceptible to assay irregularities due to matrix-induced interferences. In this study the impact of matrix interference is investigated with respect to precision and accuracy of antiarrhythmic cardiac drugs from plasma samples.