Thermo Fisher Scientific

Proteomic research facilities and laboratories are facing increasing demands for the integration of biological data from multiple '-OMICS' approaches.

Historically, within Syngenta quantitative and qualitative LC-MS analysis have been performed in parallel. Last year the Q-E was purchased to support cross-functional quan/qual projects with diverse applications throughout R&D.

In December 2000, the European Water Framework Directive (WFD) came into force and became part of UK law in December 2003. The underpinning basis of WFD was ecology driven, with the key mandated objective to provide for the planning and delivery of a better aquatic environment.

Non-covalent or native mass spectrometry holds considerable promise for routine screening of ligand libraries for binding to a target protein. Direct infusion of a protein sample in the presence of ligand from an aqueous buffer, using nano-electrospray ionisation and ‘gentle’ MS source conditions, allows detection of the protein-ligand non-covalent complex.

Methylglyoxal (MG) is an endogenous potent protein modifying agent, increased particularly in ageing, diabetes and kidney failure. It is an arginine-directed agent and often targets functionally important sites in proteins leading to inactivation.

Vitamin K1 isomers and related compounds are separated using a silica HPLC column and a normal phase solvent system.

This application presents a fast, easy, and cost-effective method for the determination of 24 pesticide residues in red wine.

To couple high-resolution pellicular anion-exchange liquid chromatography (pAXLC) of oligonucleotides with HRAM mass spectrometry (MS) and automated desalting to identify impurities and isomeric variants in synthetic oligonucleotides

To develop an efficient high-performance liquid chromatography (HPLC) method for the sensitive determination of 14 explosives and related substances in tap water

Carbonyl compounds are known to cause adverse effects on human health and many of these compounds are listed by the U. S. EPA in the Health Effects Notebook for Hazardous Air Pollutants.