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Tosoh

Application Notes by Tosoh

HPLC Column for quick Evaluation of ADCC Activity

| Contributed by Tosoh

Tosoh Bioscience introduced TSKgel FcR-IIIA-NPR a new HPLC affinity column based on recombinant FcγIIIa receptor, a key player in ADCC.

Analysis of Therapeutic Oligonucleotides by UHPSEC-MALS

| Contributed by Tosoh

The oligonucleotide therapeutics field has seen remarkable progress over the last few years and oligonucleotides are increasingly recognized as...

Analysis of Therapeutic Oligonucleotides by SEC-MALS

| Contributed by Tosoh

Oligonucleotides are increasingly recognized as therapeutics.

Correlation of FcR Affinity Chromatography with Glycan Pattern and ADCC Activity of a Therapeutic Antibody

| Contributed by Tosoh

Antibody-dependent cell-mediated cytotoxicity (ADCC) is an important mechanism of action (MoA) of monoclonal antibodies used in cancer treatment.

Evaluation of mAb ADCC Activity through Fc Receptor Affinity Chromatography

| Contributed by Tosoh

Antibody-dependent cell-mediated cytotoxicity is a mechanism of action of anti-tumor antibodies in which the Fcy receptor (FcR) plays a key role.

Determination of the Molar Mass Distribution of Phenol-Formaldehyde Resins Using GPC

| Contributed by Tosoh

Phenol formaldehyde resins (PFRs) are condensation polymers and are obtained by condensing phenol with formaldehyde in the presence of an acidic or alkaline catalyst.

UHP-SEC Analysis of Biosimilars Using Size Exclusion Chromatography

| Contributed by Tosoh

The amounts of high and low molecular weight impurities are critical quality attributes for a therapeutic protein.

SEC/MS Analysis of a Bispecific Antibody

| Contributed by Tosoh

More potent formats of monoclonal antibodies (mAbs), such as bispecific antibodies (bsAbs), are on the rise in the area of biotherapeutics.

Fields & Applications Pharma & Biopharma

Analysis of mAb aggregates by SE-UHPLC

| Contributed by Tosoh

Learn how to apply SEC technology most efficiently to establish a fast, highly reproducible, and accurate SE-UHPLC method for mAb aggregate analysis.

Fields & Applications Pharma & Biopharma

Increased Monoclonal Antibody Resolution in UHPLC

| Contributed by Tosoh

With the introduction of TSKgel UP-SW3000 silica-based UHPLC columns increased speed and higher resolution can be achieved for the separation of antibody fragments, monomers, and dimers.

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