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Tosoh

Application Notes by Tosoh

Fields & Applications Pharma & Biopharma

DAR Analysis of Antibody-Drug Conjugates

| Contributed by Tosoh

An Antibody-Drug Conjugate (ADC) was analyzed using a TSKgel® Butyl-NPR column, the least hydrophobic of the TSKgel HIC columns

DAR Analysis of Antibody Drug Conjugates (ADC)

| Contributed by Tosoh

Antibody-drug conjugates (ADCs) represent some of the most promising next-generation biopharmaceuticals.

Analysis of Monoclonal Antibody and Protein Aggregates Induced by Denaturation using a Novel SEC Column

| Contributed by Tosoh

This application note will show the superior resolving power of the TSKgel UltraSW Aggregate column for the analysis of monoclonal antibody and metalloprotein aggregates formed under forced denatured conditions.

Fast Analysis of IgG Charge Heterogeneity by Ion Exchange Chromatography

| Contributed by Tosoh

Evaluation of strong and weak cation exchange columns and dependence of separation on mobile phase PH.

UHPLC Glycosylation Analysis with TSKgel Amide-80 2 μm HILIC Columns

| Contributed by Tosoh

Glycosylation is one of the most common forms of post-translational modification of proteins.

DAR Analysis of Antibody-Drug Conjugate by Hydrophobic Interaction Chromatography

| Contributed by Tosoh

In this application note an ADC was analyzed using a TSKgel Butyl-NPR column.

Rapid and Accurate Therapeutic mAb Aggregate Analysis Using TSKgel® UP-SW3000, 2 μm, SEC Column

| Contributed by Tosoh

This application describes the use of a 4.6 mm ID × 15 cm TSKgel UP-SW3000 SEC column for fast and accurate mAb aggregate analysis without compromising the quality of the aggregate determination or reproducibility.

Fast Monoclonal Antibody Titer Determination with TSKgel® Protein A-5PW

| Contributed by Tosoh

In this application note, the quick capture and accurate titer analysis over a wide concentration range of mAb is demonstrated using a TSKgel Protein A-5PW analytical column.

Increased Monoclonal Antibody Resolution in UHPLC

| Contributed by Tosoh

With the introduction of TSKgel UP-SW3000 silica-based UHPLC columns increased speed and higher resolution can be achieved for the separation of antibody fragments, monomers, and dimers. These size exclusion columns feature the same pore size as the renowned TSKgel G3000SWXL.

Increased Monoclonal Antibody Resolution with TSKgel® UP-SW3000 ColumnsDetector

| Contributed by Tosoh

The antibody therapeutics market is enjoying high growth rates, the major areas of therapeutic application being cancer and immune/inflammation-related disorders

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