Wound Healing in Diabetes

Applying an inclusive analysis that requires minimal sample manipulation to generate robust biomolecular signatures from diabetic wound fluid

Chronic ulcerative wounds are a distressing and common complication of diabetes. To help determine the processes that prevent normal wound repair in diabetic patients, the McLean Research Group based at Vanderbilt University, Tennessee, used ion mobility-mass spectrometry (IM-MS) to analyze wound fluid (a complex brew of byproducts of the wound repair process) from sponges implanted into the wounds of diabetic and control rats. Here, Kelly M. Hines, lead author of the group’s recent paper (1) answers questions about the research.