Debilitating and often incurable, neurodegenerative diseases could affect over 12 million Americans by 2030 (1). Finding treatments – or, even better, cures – for these conditions is a high priority. But first, we need to understand them.
High levels of metal ions in the cerebrospinal fluid (CSF) are currently thought to play a key role in protein misfolding – a hallmark of neurogenerative disorders – so a multinational team of researchers developed a method for simultaneous redox speciation of iron (II/III), manganese (II/III), and copper (I/II). Based on strong cation exchange chromatography and inductively coupled plasma sector field mass spectrometry (ICP-sf-MS), the new method was optimized and tested using real CSF samples taken from amyotrophic lateral sclerosis (ALS) patients and neurologically healthy controls (2).
Enjoy our FREE content!
Log in or register to read this article in full and gain access to The Analytical Scientist’s entire content archive. It’s FREE and always will be!
If you don’t have an account you can:
REGISTER NOW – it’s FREE and always will be!
You will benefit from:
- Unlimited access to ALL articles including Application Notes
- News, interviews & opinions from leading industry experts
- Receive print (and PDF) copies of The Analytical Scientist magazine
Or Login as a Guest or via Social Media
This will allow you to read this article but you will only have limited access to The Analytical Scientist.Login as Guest Facebook Google+ LinkedIn Twitter