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Preparative/Process Chromatography

Techniques & Tools Spectroscopy

Think Twice

(Re)developing twin column “recycling” chromatography to separate and identify trace impurities

Techniques & Tools Liquid Chromatography

Curator of Good Science

Ian Wilson on chemistry sets, big pharma, and why you should always hire people smarter than you

Techniques & Tools Pharma & Biopharma

Prepping for PREP

| Charlotte Barker

Symposium Chair Giorgio Carta tells us what we can expect from PREP 2017 in Philadelphia

Business & Education Sample Preparation

Protein measurements with the Zetasizer µV

This application note describes a selection of measurements made on a GE AKTA basic system. Since the unit only contains a UV detector for measuring sample concentration, this can be used for the molecular weight calculations instead of the more commonly used refractive index detector, provided that the molar extinction coefficient of the sample protein is known. If this is not known, then reliable estimates can be made based on the amino acid sequence of the sample.

Techniques & Tools Sample Preparation

Performance of Polymer Solutions for Enhanced Oil Recovery

In this article we take an introductory look at work carried out by TU Clausthal to develop an improved understanding of the mechanisms of enhanced oil recovery (EOR) by polymer flooding, and the relevance of fluid rheology. Example data illustrates the insight that rheology provides and its application in optimizing fluid performance.

Business & Education Sample Preparation

Why should I upgrade to multi-detection GPC?

10 reasons for polymer characterization scientists. Gel-permeation chromatography (GPC) is an essential tool for the characterization of polymers. It allows polymer scientists to tailor a polymer’s properties to its end use requirements by controlling its molecular properties, since the two are inextricably linked.

Business & Education Sensors

Case studies: Ink formulation's analytical strategies

This white paper offers practical guidance on using a range of analytical techniques, including rheology, particle size and zeta potential measurement to assist in the formulation of Inkjet inks.

Techniques & Tools Sample Preparation

Solvent Enhanced Light Scattering of Fluoro-Polyester

Traditionally in GPC, the sample dissolution solvent and the mobile phase are one and the same. However, a closer look at the demands of sample solvent and mobile phase suggests that this should not always be the case.

Business & Education Sample Preparation

Detection and quantification of large protein aggregates

The complementarities of two techniques, dynamic light scattering (DLS) and static light scattering detector coupled with a size exclusion chromatography system (SEC-LS), are illustrated by studying a number of samples where a thermally denatured and aggregated protein sample were dosed at different levels into a non-denatured protein sample.

Business & Education Sample Preparation

Intrinsic viscosity measurements on sRAGE protein

In this application note, intrinsic viscosity measurements were performed on the sRAGE protein to establish whether the detector was able to detect and characterize the conformational change induced by the presence of calcium. Light scattering molecular weight measurements were also performed. Data are also presented showing that the conformation of sRAGE changes in the presence and absence of calcium.


Latest Application Notes

Impurity isolation and API purification by SFC

| Contributed by Kromasil

Automated SW solution for preparative HPLC:

| Contributed by DataApex

Automated SW solution for preparative HPLC:

| Contributed by DataApex

All Application Notes

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