The Analytical Scientist Power List returns to celebrate the successes of the field’s leading lights!
09/20/2016 | Rich Whitworth
…our ‘mini magazine’ dedicated to medical cannabis
09/06/2016 | Sponsored by Malvern Panalytical
10 reasons for polymer characterization scientists. Gel-permeation chromatography (GPC) is an essential tool for the characterization of polymers. It allows polymer scientists to tailor a polymer’s properties to its end use requirements by controlling its molecular properties, since the two are inextricably linked.
Nanoparticle Tracking Analysis (NTA) has found use in a variety of investigations researching the toxicity and environmental impact of nanoparticles. Here we discuss various publications in which NTA has been used to measure particle size and concentration of nanomaterials in waste water.
08/15/2016 | Rich Whitworth, Marcus Lippold
Products, partnerships, investments - what’s going on in the analytical science business world.
08/03/2016 | Sponsored by Malvern Panalytical
This whitepaper reviews the methods available for measuring the key characteristics of polymers focusing on the benefits and value of gel permeation / size exclusion chromatography (GPC/SEC). Much of the paper talks exclusively about polymers, however many of the principles discussed are equally applicable to proteins or protein conjugate materials.
Traditionally in GPC, the sample dissolution solvent and the mobile phase are one and the same. However, a closer look at the demands of sample solvent and mobile phase suggests that this should not always be the case.
The complementarities of two techniques, dynamic light scattering (DLS) and static light scattering detector coupled with a size exclusion chromatography system (SEC-LS), are illustrated by studying a number of samples where a thermally denatured and aggregated protein sample were dosed at different levels into a non-denatured protein sample.
In this application note, intrinsic viscosity measurements were performed on the sRAGE protein to establish whether the detector was able to detect and characterize the conformational change induced by the presence of calcium. Light scattering molecular weight measurements were also performed. Data are also presented showing that the conformation of sRAGE changes in the presence and absence of calcium.
07/14/2016 | Sebastian Pantò
A new instrument could help with obtaining pure components from complex natural samples.
06/17/2016 | Sponsored by Malvern Panalytical
This article explores how multiple detectors, particularly light scattering detectors, may be used for size-exclusion chromatography (SEC) in protein analysis. Using a light scattering detector as part of a multi-detector Size Exclusion Chromatography system provides the accurate molecular weight (MW) data needed to assess the activity, safety and clinical efficacy of therapeutic proteins.
Register to access our FREE online portfolio, request the magazine in print and manage your preferences.
Register
Thinking “In Green”
Zooming In on Nanoplastics
The Easy – and USP Compliant – Way to Modernize Your HPLC Methods