Multi Attribute Method and Native Intact Mass Spectrometry for Characterization of Quality Attributes During Pharmaceutical Development of mAb Mixtures
Case studies employing LC MS and native mass spectrometry for characterization and control of CQAs during biopharmaceutical development will be presented.
sponsored by Thermo Fisher
Symphogen develops anti-cancer mAb mixtures, which are inherently complex and difficult to characterize using conventional technologies (e.g. methods relying exclusively on chromatographic resolution).
To address product complexity, and meet regulatory demands, Symphogen is looking increasingly to mass spectrometry for qualitative and quantitative control of critical quality attributes (CQAs).
Case studies employing LC MS (Multiple-Attribute Method, MAM) and native mass spectrometry for characterization and control of CQAs during biopharmaceutical development will be presented.
What you can learn:
- Learn how peptide mapping using high resolution accurate mass (HRAM) mass spectrometry provides the necessary chromatographic and mass spectral resolution to allow control of critical quality attributes (CQAs) in complex mAb mixtures.
- Learn how the same high resolution MS Platform can be used for peptide mapping and native mass spectrometry characterization of biopharmaceuticals.
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