Analysis of caffeine in energy drinks with Thin Layer Chromatography coupled to MS

Introduction

The analysis and quantification of caffeine is performed using an elution based “TLC – MS interface” coupled with an “expression CMS”. Because of the high matrix tolerance of TLC no sample preparation is needed. The energy drinks are applied directly on the high performance thin layer chromatography (HPTLC) Si60 F₂₅₄ MS grade plate.

TLC – MS Interface (left), expression CMS (right)

Chromatographic Conditions

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