The Analytical Scientist / App Notes / 2016 / EP/USP GPC/SEC Molar Mass Determination for Low Molecular Weight Heparin (LMWH)

EP/USP GPC/SEC Molar Mass Determination for Low Molecular Weight Heparin (LMWH)

07/18/2016

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LMWHs are defined as heparin salts having an average molecular weight of less than 8000 Da. Both, the Pharmaeuropa and the US Pharmacopeia, require GPC/SEC to characterize e.g. Enoxaparin Sodium or other low molar mass heparins with respect to molecular weight. A dedicated GPC/SEC software such as PSS WinGPC UniChrom is required to obtain reliable mass fraction information.


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