Cannabidiol (CBD) is a non-psychoactive cannabinoid which has an easing, anti-inflammatory and antianxiety effect and is used to ease nausea. Melatonin is a hormone from serotonin and controls the day-night rhythm. For this reason, an American customer was interested in developing a sleeping aid containing both ingredients. Therefore, YMC was asked to develop a simplified method for the quantitative analysis of CBD and melatonin at a ratio of 5:1.
Due to its versatile column chemistry YMC-Triart C18 columns are the perfect starting point for method development. The high lot-to-lot reproducibility of YMC-Triart C18 will ensure accurate results which is important for quality control.
This application note shows how to obtain a fast separation of CBD and melatonin with excellent peak shapes. The analysis is performed in only 7 minutes under gradient conditions using an YMC-Triart C18 HPLC column with 3 µm particles.
>> Download the Full Application Note as a PDF
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