Conexiant
Login
  • The Analytical Scientist
  • The Cannabis Scientist
  • The Medicine Maker
  • The Ophthalmologist
  • The Pathologist
  • The Traditional Scientist
The Analytical Scientist
  • Explore

    Explore

    • Latest
    • News & Research
    • Trends & Challenges
    • Keynote Interviews
    • Opinion & Personal Narratives
    • Product Profiles
    • App Notes

    Featured Topics

    • Mass Spectrometry
    • Chromatography
    • Spectroscopy

    Issues

    • Latest Issue
    • Archive
  • Topics

    Techniques & Tools

    • Mass Spectrometry
    • Chromatography
    • Spectroscopy
    • Microscopy
    • Sensors
    • Data and AI

    • View All Topics

    Applications & Fields

    • Clinical
    • Environmental
    • Food, Beverage & Agriculture
    • Pharma and Biopharma
    • Omics
    • Forensics
  • People & Profiles

    People & Profiles

    • Power List
    • Voices in the Community
    • Sitting Down With
    • Authors & Contributors
  • Business & Education

    Business & Education

    • Innovation
    • Business & Entrepreneurship
    • Career Pathways
  • Events
    • Live Events
    • Webinars
  • Multimedia
    • Video
Subscribe
Subscribe

False

The Analytical Scientist / App Notes / 2021 / UHPLC Analysis of 6 common nitrosamines using YMC-Triart C18

UHPLC Analysis of 6 common nitrosamines using YMC-Triart C18

08/18/2021

Share

Featured Image

N-Nitrosamines are a class of small organic compounds with the chemical structure R1R2-N-N=O where R1 and R2 are usually alkyl groups. They are typically formed from secondary amines reacting with nitrosating agents (such as nitrite) under acidic conditions. These compounds are found in food, especially cured meat products, as well as tobacco, consumer products, cosmetics and drugs. Impurities in drugs could be found in antihypertensives, gastric acid blockers and antidiabetics drugs. Additionally, nitrosamines can be formed in the mouth or stomach due to the acidic pH that prevails there. Based on animal studies, it is assumed that nitrosamines are probable human carcinogens that may produce cancer in a range of organs. For this reason, the European Medicines Agency (EMA) already set maximum limits for the daily dose of various nitrosamines in drugs. These compounds also need to be monitored in several industries, such as in the food industry, pharma industry and in the production of children’s toys.

Therefore, reliable analyses are essential for accurate quantification. In this application note, 6 nitrosamines are separated using YMC-Triart C18. The chromatogram shows that the analysis of nitrosamines can be quite challenging. A stable baseline is a crucial factor in order to determine the small peaks that are commonly observed in nitrosamine analysis due to their low concentrations as impurities. Good separation and resolution can be achieved by using a YMC-Triart C18 column which makes it an ideal choice for sensitive analyses such as this.

>> Download the Full Application Note as a PDF

Newsletters

Receive the latest analytical scientist news, personalities, education, and career development – weekly to your inbox.

Newsletter Signup Image

Explore More in Analytical Science

Dive deeper into the analytical science. Explore the latest articles, case studies, expert insights, and groundbreaking research.

False

Advertisement

Recommended

False

Related Content

Removing User Bias from Structure Verification by NMR
Removing User Bias from Structure Verification by NMR

November 15, 2021

Chemical structure verification by NMR is one of t...

Simultaneous Determination of Eight Nitrosamine Impurities in Metformin Extended-Release Tablets Using the Agilent 6470 Triple Quadrupole LC/MS
Simultaneous Determination of Eight Nitrosamine Impurities in Metformin Extended-Release Tablets Using the Agilent 6470 Triple Quadrupole LC/MS

November 15, 2021

Detection of regulated genotoxic impurities from t...

HIGH RESOLUTION MULTI-REFLECTING TIME-OF-FLIGHT MASS ANALYZER WITH FOLDED FLIGHT PATH®
HIGH RESOLUTION MULTI-REFLECTING TIME-OF-FLIGHT MASS ANALYZER WITH FOLDED FLIGHT PATH®

November 15, 2021

How high does resolving power need to be?

Biomarker discovery
Biomarker discovery

November 16, 2021

Essential guide to analysing VOCs in breath and other biological samples...

False

The Analytical Scientist
Subscribe

About

  • About Us
  • Work at Conexiant Europe
  • Terms and Conditions
  • Privacy Policy
  • Advertise With Us
  • Contact Us

Copyright © 2025 Texere Publishing Limited (trading as Conexiant), with registered number 08113419 whose registered office is at Booths No. 1, Booths Park, Chelford Road, Knutsford, England, WA16 8GS.