Conexiant
Login
  • The Analytical Scientist
  • The Cannabis Scientist
  • The Medicine Maker
  • The Ophthalmologist
  • The Pathologist
  • The Traditional Scientist
The Analytical Scientist
  • Explore

    Explore

    • Latest
    • News & Research
    • Trends & Challenges
    • Keynote Interviews
    • Opinion & Personal Narratives
    • Product Profiles
    • App Notes

    Featured Topics

    • Mass Spectrometry
    • Chromatography
    • Spectroscopy

    Issues

    • Latest Issue
    • Archive
  • Topics

    Techniques & Tools

    • Mass Spectrometry
    • Chromatography
    • Spectroscopy
    • Microscopy
    • Sensors
    • Data and AI

    • View All Topics

    Applications & Fields

    • Clinical
    • Environmental
    • Food, Beverage & Agriculture
    • Pharma and Biopharma
    • Omics
    • Forensics
  • People & Profiles

    People & Profiles

    • Power List
    • Voices in the Community
    • Sitting Down With
    • Authors & Contributors
  • Business & Education

    Business & Education

    • Innovation
    • Business & Entrepreneurship
    • Career Pathways
  • Events
    • Live Events
    • Webinars
  • Multimedia
    • Video
Subscribe
Subscribe

False

The Analytical Scientist / App Notes / 2022 / Characterization of MAbs Using FcR-Affinity and HILIC-MS

Characterization of MAbs Using FcR-Affinity and HILIC-MS

06/16/2022

Share

Featured Image

Combining FcR-IIIA affinity separation with HILIC-MS analysis allows rapid screening of antibodies. HILIC-MS confirms the presence and relative quantity of N-glycans in different mAb glycoform fractions for in-depth characterization.

Monoclonal antibodies (mAbs) are an important class of therapeutics with the immense capacity to treat multiple diseases. Due to the complex nature and glycan heterogeneity of these products, characterization and strict control of their critical quality attributes is necessary to maintain product quality and efficacy. The mAb glycans linked to the Asn-297 glycosylation site on the Fc region impact biologic activities such as antibody-dependent cellular cytotoxicity (ADCC) and stability.

>> Download the Application Note as a PDF

Newsletters

Receive the latest analytical scientist news, personalities, education, and career development – weekly to your inbox.

Newsletter Signup Image

Explore More in Analytical Science

Dive deeper into the analytical science. Explore the latest articles, case studies, expert insights, and groundbreaking research.

False

Advertisement

Recommended

False

Related Content

Optimizing metal powders for Isostatic Pressing
Optimizing metal powders for Isostatic Pressing

January 4, 2022

Isostatic pressing has several benefits over the c...

Monitoring respirable silica at workplace
Monitoring respirable silica at workplace

January 5, 2022

Stringent regulations of occupational exposure to ...

Analytical toolkit for the optimization of battery electrode materials
Analytical toolkit for the optimization of battery electrode materials

January 7, 2022

Modern batteries like lithium-ion have revolutioni...

Analysis of catalytic ink for proton exchange membrane fuel cells (PEMFC’s)
Analysis of catalytic ink for proton exchange membrane fuel cells (PEMFC’s)

January 10, 2022

Catalytic inks are the key component when balancin...

False

The Analytical Scientist
Subscribe

About

  • About Us
  • Work at Conexiant Europe
  • Terms and Conditions
  • Privacy Policy
  • Advertise With Us
  • Contact Us

Copyright © 2025 Texere Publishing Limited (trading as Conexiant), with registered number 08113419 whose registered office is at Booths No. 1, Booths Park, Chelford Road, Knutsford, England, WA16 8GS.