3D human in vitro cell models are gaining increased importance in the drug discovery and development cycle of the pharmaceutical industry as they mimic the human in vivo responses of newly developed substances more precisely than 2D models. They can help to bridge the gap between the traditional 2D in vitro models and whole-animal systems as the traditional models do not effectively recapitulate the more complex signalling and cellular interactions found in vivo. Spheroids are scaffold-free 3D cell culture models that are aggregated from one or more organ-specific cell types.
InSphero has developed 3D cell-based assay solutions in the fields of liver toxicology, metabolic diseases, and oncology. Industrial use of these complex in vitro systems requires a perfect match of the tissue model, cell culture plates and liquid handling instrumentation. InSphero’s Akura™ 96 and 384 Spheroid Microplates have been engineered for the generation, long-term cultivation, observation and testing of spheroids in 96 and 384 well formats in a simple, flexible, and automation-compatible platform. Its scalable format requires liquid handling systems for convenient, yet quick, reliable, and precise medium exchange, sampling, dosing, and spheroid transfer from multiple plates. The semiautomated VIAFLO 96 and VIAFLO 384 electronic pipettes are ideal for these routine lab tasks, offering 96 and 384 channel pipetting in a compact and easy-to-use platform, for increased productivity.
>> Download the Application Note as a PDF
Newsletters
Receive the latest analytical scientist news, personalities, education, and career development – weekly to your inbox.
