As mass spectrometry instrumentation becomes faster and more sensitive, overall method time, resolution and depth of analysis are now limited by separation methods. To enhance overall front-end separatory techniques, post-ionization gas-phase separations have become more common in conjunction with traditional liquid separations prior to mass analysis. The use of ion mobility-mass spectrometry (IM-MS) can significantly reduce analysis times and improve resolution of glycan isomers compared to LC-MS alone. IM-MS platforms have become commercially available and the importance of this additional dimension of separation is now being realized in industry settings.
The High-Resolution on Mobility-Mass Spectrometry (HRIM-MS) platform MOBIETM demonstrates great potential for revealing complex glycoform profiles3 and, in combination with LC, yields multiple dimensions of information for feature determination and quantitation.
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