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Analysis of commercial monoclonal antibodies by microLC-MS/MS

Monoclonal antibodies (MAbs) are high-potency agents mainly used in cancer therapy or to combat auto-immune diseases. Even small amounts of these substances can have severe effects even when taken accidently.

Therefore, it is of interest to analyse different kinds of samples which could contain these antibodies, e.g. solutions prepared for patient application (usually a dilution of the dosage form). By use of microLC-MS/ MS, only a very small amount of this valuable solution is required to identify and quantify the monoclonal antibody in very short run times.

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