Analysis of Large Immunoglobulins by UHPSEC

Antibody therapeutics are still enjoying high growth rates. Today new antibody formats are entering clinical phases some of which are larger than conventional mAbs. The characterization of these complex molecules with regard to high molecular weight (HMW) and low molecular weight (LMW) impurities is needed in R & D, process monitoring and quality control.

contributed by Tosoh | 07/16/2020

A new application note describes the advantages of using a new size exclusion UHPLC column for the determination of higher order mAb aggregates or larger immunoglobulin classes, such as IgM. This SEC column is featuring the largest pore size within the renowned TSKgel UP-SW series and was designed to meet the requirements of users analyzing biomolecules with higher molecular weight than standard IgG.

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