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Analysis of Therapeutic Oligonucleotides by UHPSEC-MALS

A new application note describes the ability of size-exclusion chromatography to discriminate oligonucleotides differing by one base in length when using UHPLC or UHPLC-MALS. For this purpose, a new silica gel-based phase, TSKgel UPSW2000, with a pore size of 12.5 nm was applied, which is also perfectly suited for the analysis of smaller proteins and peptide aggregates.

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