Cookies

Like most websites The Analytical Scientist uses cookies. In order to deliver a personalized, responsive service and to improve the site, we remember and store information about how you use it. Learn more.

ASPIRIN® Decomposition Studies by TG-FTIR

Introduction

The supply of pharmaceutical products depends on the storage stability of the active ingredient in the formulation. Therefore, the decomposition behavior of the active ingredient is very important in determining the shelf life of a pharmaceutical product. Knowledge of the decomposition products from the active ingredient is useful in helping to avoid the occurrence of undesired by-products, which form during storage.

Application

The analysis objective is to monitor and identify decomposition behavior and thermal stability in pharmaceutical formulations. TG-FT-IR method was used under the following circumstances and samples:

  • g Sample: 9.89mg Acetylsalicylic Acid (ASPIRIN® pulverized tablet)
  • g Sample: crucible; Al2O3 type
  • g Flowrate: 45ml/min; N2
  • For simultaneous FT-IR measurement, a spectral resolution of 4cm-1, in the spectral range from 650 - 5000cm-1 are used. Spectra were recorded approximately every 15 seconds.
Read the full article now

Log in or register to read this article in full and gain access to The Analytical Scientist’s entire content archive. It’s FREE!

Login
Receive content, products, events as well as relevant industry updates from The Analytical Scientist and its sponsors.

When you click “Subscribe” we will email you a link, which you must click to verify the email address above and activate your subscription. If you do not receive this email, please contact us at [email protected].
If you wish to unsubscribe, you can update your preferences at any point.

Register to The Analytical Scientist

Register to access our FREE online portfolio, request the magazine in print and manage your preferences.

You will benefit from:
  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Analytical Scientist magazine

Register