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ASPIRIN® Decomposition Studies by TG-FTIR


The supply of pharmaceutical products depends on the storage stability of the active ingredient in the formulation. Therefore, the decomposition behavior of the active ingredient is very important in determining the shelf life of a pharmaceutical product. Knowledge of the decomposition products from the active ingredient is useful in helping to avoid the occurrence of undesired by-products, which form during storage.


The analysis objective is to monitor and identify decomposition behavior and thermal stability in pharmaceutical formulations. TG-FT-IR method was used under the following circumstances and samples:

  • g Sample: 9.89mg Acetylsalicylic Acid (ASPIRIN® pulverized tablet)
  • g Sample: crucible; Al2O3 type
  • g Flowrate: 45ml/min; N2
  • For simultaneous FT-IR measurement, a spectral resolution of 4cm-1, in the spectral range from 650 - 5000cm-1 are used. Spectra were recorded approximately every 15 seconds.
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