Introduction
This Bulletin shows the possibility to automatically measure low conductivity of water samples according to USP 645. Especially sterile water samples, which are further used to prepare, e.g., injections, are measured according to this norm.
The USP describes a three step analysis. The first step consists of measuring the conductivity and comparing it to a conductivity limit correlated to the measured temperature. If the limit is not met, the second step is carried out. Here, the sample is tempered to 25 ± 1 °C followed by a conductivity measurement. If the given conductivity limit of 2.1 μS/cm is exceeded, the analysis will pass over to the third step in which the pH is measured. The measured conductivity of the second step is compared to given pH dependent limiting values.
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