Automated SPE–LC–MS/MS determination of psychoactive drugs in Plasma and serum

contributed by Gerstel | 09/07/2022

Determination of psychoactive drugs in the context of clinical and forensic toxicology, down to the low ng/mL range from only 250 μL of blood plasma or serum, is described in this work. A compre- hensively automated “multi method” based on solid-phase ex- traction (SPE) coupled online to LC–MS/MS is used to determine 65 compounds, including benzodiazepines, various sedatives, antidepressants, antipsychotics, methadone, and their relevant metabolites. The method has been fully validated for 52 of those compounds following the guidelines of the Society of Toxicologi- cal and Forensic Chemistry (GTFCh). Semi-quantitative or qualita- tive determination of some less relevant drugs and metabolites is also included in this work.

Log in or register to read this article in full and gain access to The Analytical Scientist’s entire content archive. It’s FREE!

Email*

Choose a password*

I have read and understand the Privacy Notice *

Stay up to date with our other newsletters and sponsors information, tailored specifically to the fields you are interested in

Receive communication from The Cannabis Scientist I want to stay up to date with the Mass Spectrometry field I want to stay up to date with the Spectroscopy field

When you click “Subscribe” we will email you a link, which you must click to verify the email address above and activate your subscription. If you do not receive this email, please contact us at [email protected].
If you wish to unsubscribe, you can update your preferences at any point.