Conexiant
Login
  • The Analytical Scientist
  • The Cannabis Scientist
  • The Medicine Maker
  • The Ophthalmologist
  • The Pathologist
  • The Traditional Scientist
The Analytical Scientist
  • Explore

    Explore

    • Latest
    • News & Research
    • Trends & Challenges
    • Keynote Interviews
    • Opinion & Personal Narratives
    • Product Profiles
    • App Notes

    Featured Topics

    • Mass Spectrometry
    • Chromatography
    • Spectroscopy

    Issues

    • Latest Issue
    • Archive
  • Topics

    Techniques & Tools

    • Mass Spectrometry
    • Chromatography
    • Spectroscopy
    • Microscopy
    • Sensors
    • Data and AI

    • View All Topics

    Applications & Fields

    • Clinical
    • Environmental
    • Food, Beverage & Agriculture
    • Pharma and Biopharma
    • Omics
    • Forensics
  • People & Profiles

    People & Profiles

    • Power List
    • Voices in the Community
    • Sitting Down With
    • Authors & Contributors
  • Business & Education

    Business & Education

    • Innovation
    • Business & Entrepreneurship
    • Career Pathways
  • Events
    • Live Events
    • Webinars
  • Multimedia
    • Video
Subscribe
Subscribe

False

The Analytical Scientist / App Notes / 2021 / Automated TD Sample Preparartion of Calibration Standards

Automated TD Sample Preparartion of Calibration Standards

10/04/2021

Share

Featured Image

This application note demonstrates quantitative sample preparation of calibration standards using the CDS 7550S automated thermal desorber. The internal standard loop of the 7550S is utilized here to automate the process of preparing calibration standards onto pre-conditioned thermal desorption tubes.

Gas chromatography (GC) is an analytical technique by separating a mixture of compounds for a downstream detector to identify the chemical composition of each component. Direct liquid injection intot the GC inlet is the most common method of introducing sample onto the GC column. However, in many situations, the analyte identity, analyte concentration, or the matrix are not compatible for GC analysis. To tackle this challenge, various sample introduction techniques, including Purge and Trap, Thermal Desorption, Pyrolysis, and Solid Phase Micro Extraction were developed to introduce analyte onto the GC column to achieve the best separation result.

Here the CDS 7550S automated Thermal Desorber incorporates a sample concentration feature, which is designed to assist in sample preparation of calibration standards. Sample concentration works successively adding one more aliquots of standard gas directly from a sample loop of a known volume.

A CDS 7550S automated thermal desorber with the internal standard and Peltier options. In concentration mode, calibration standard is added directly to the sample tube.The calibration standard that was used was a pre-mixed 1 ppmv gas used for EPA TO-15 containing 65 analytes (Restek PN 34436). This was done for four total samples in which one, two, three, and four aliquouts of standard gas were added to each tube. The volume of the sample loop is 5 mL. After the standard was added into each tube, the sample tube was returned the autosampler rack where the tube was stored until all calibration standards were prepared. Once all samples were prepared, the VOCs were desorbed from the thermal desorption sample tube to the analytical focus trapped electronically cooled by a Peltier unit. The sample tube was manufactured by Camsco and packed with Carbograph 1/Carbograph 2/Carboxen 1000 (P/N SU644-4).

>> Download the full Application Note as PDF

More information

Newsletters

Receive the latest analytical scientist news, personalities, education, and career development – weekly to your inbox.

Newsletter Signup Image

Explore More in Analytical Science

Dive deeper into the analytical science. Explore the latest articles, case studies, expert insights, and groundbreaking research.

False

Advertisement

Recommended

False

Related Content

Removing User Bias from Structure Verification by NMR
Removing User Bias from Structure Verification by NMR

November 15, 2021

Chemical structure verification by NMR is one of t...

Simultaneous Determination of Eight Nitrosamine Impurities in Metformin Extended-Release Tablets Using the Agilent 6470 Triple Quadrupole LC/MS
Simultaneous Determination of Eight Nitrosamine Impurities in Metformin Extended-Release Tablets Using the Agilent 6470 Triple Quadrupole LC/MS

November 15, 2021

Detection of regulated genotoxic impurities from t...

HIGH RESOLUTION MULTI-REFLECTING TIME-OF-FLIGHT MASS ANALYZER WITH FOLDED FLIGHT PATH®
HIGH RESOLUTION MULTI-REFLECTING TIME-OF-FLIGHT MASS ANALYZER WITH FOLDED FLIGHT PATH®

November 15, 2021

How high does resolving power need to be?

Biomarker discovery
Biomarker discovery

November 16, 2021

Essential guide to analysing VOCs in breath and other biological samples...

False

The Analytical Scientist
Subscribe

About

  • About Us
  • Work at Conexiant Europe
  • Terms and Conditions
  • Privacy Policy
  • Advertise With Us
  • Contact Us

Copyright © 2025 Texere Publishing Limited (trading as Conexiant), with registered number 08113419 whose registered office is at Booths No. 1, Booths Park, Chelford Road, Knutsford, England, WA16 8GS.