Cold Medicine API Screen Using a Kinetex® EVO C18 Core-Shell LC Column

contributed by Phenomenex | 05/29/2015

The current range of compounds aimed at the treatment of the common cold is quite large and comprises ingredients of a variety of chemical characteristics. This is the direct result of a diverse array of pharmaceutical formulations that contain more than one active ingredient and target multiple symptoms at once. With such a mixture of polar compounds, resolution, sensitivity, and speed are all important parameters. Using a high performance core-shell Kinetex 2.6 μm EVO C18 column we achieve comprehensive resolution, narrow peak shapes, and a rapid analysis time. This ingredient screen can easily be used as a starting point for individual formulations as well as transferred between R&D and QC instrumentation due to the direct scalability of all three Kinetex EVO C18 particle sizes (1.7 μm, 2.6 μm, 5 μm).

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