Comprehensive separation of a graft copolymer by GPC/SEC and Polymer-HPLC (LAC)

contributed by PSS | 06/10/2015

GPC/SEC offers powerful multi detection options for copolymers but separates only size-based. Polymer-HPLC is used to detect species not to be resolved by GPC/SEC.

Graft copolymers are complex products as they exhibit a molar mass and a chemical composition distribution simultaneously. During synthesis side reactions as the formation of homopolymers due to non-grafted species may occur. GPC/SEC dual detection can be used to determine the concentration profiles of the comonomers as function of molecular size, if e.g. one of the comonomers contains chromophores. Polymer-HPLC (Liquid Adsorption Chromatography, LAC) separates based on composition and therefore can differentiate between sample components which cannot be resolved by GPC/SEC due to co-elution. This application note shows the results for a polystyrene-polymethyl methacrylate (PS-PMMA) graft copolymer.

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