Determination of per- and polyfluorinated alkyl substances (PFAS) in drinking water using automated solid-phase extraction and LC-MS/MS

Authors: Changling Qiu, Xin Zhang, Rahmat Ullah, Wei Chen, and Yan Liu Thermo Fisher Scientific, Sunnyvale, CA

Keywords: Perfluorinated alkyl substances, AutoTrace 280, U.S. EPA Method 537.1, Accucore RP-MS column, Vanquish Flex Duo UHPLC, TSQ Fortis triple quadrupole mass spectrometer

1. Goal

To demonstrate an efficient and reliable solid-phase extraction method with the Thermo Scientific™ Dionex™ AutoTrace™ 280 PFAS Solid-Phase Extraction instrument for the determination of per- and poly-fluorinated compounds in drinking water per U.S. EPA Method 537.1