Subscribe to Newsletter

Doxylamine Impurity Profile Using a Kinetex® EVO C18 Core-Shell LC Column


The manufacturing of a pharmaceutical product results in the accumulation of impurities from a variety of sources. Pharmaceutical regulatory agencies require that an impurity profiling testing method is utilized to ensure that the amount of impurities is below an allowable limit. As demonstrated below, a high performance core-shell Kinetex EVO C18 column obtains narrow peak shape and extremely useful resolution for a doxylamine formulation impurity profile. Unlike traditional fully porous and core-shell products, the pH 1-12 stability of the EVO C18 material allows this method to utilize a high pH mobile phase that aids in retention and separation. More so, the sharp, narrow peak shape means that more accurate quantification and therefore more reliable data is obtained.

Read the full article now

Log in or register to read this article in full and gain access to The Analytical Scientist’s entire content archive. It’s FREE!

Receive content, products, events as well as relevant industry updates from The Analytical Scientist and its sponsors.
Stay up to date with our other newsletters and sponsors information, tailored specifically to the fields you are interested in

When you click “Subscribe” we will email you a link, which you must click to verify the email address above and activate your subscription. If you do not receive this email, please contact us at [email protected].
If you wish to unsubscribe, you can update your preferences at any point.

Register to The Analytical Scientist

Register to access our FREE online portfolio, request the magazine in print and manage your preferences.

You will benefit from:
  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Analytical Scientist magazine