Exploring Extra Sensitivity Using ionKey/MS with the Xevo G2-XS Q-Tof HRMS for Small Molecule Pharmaceutical Analysis in Human Plasma

contributed by Waters | 06/17/2015

The need for unambiguous data to support milestone transition and compound selection for drug discovery and development has fueled an unrelenting desire for instruments with higher sensitivity. Consequently sensitivity enhancement has been a critical attribute in each evolution of modern LC-MS instrumentation.

To address this need, Waters has focused on integrating and optimizing both the inlet and the MS detector. The ionKey/MS System integrates the separation into the source of the Xevo^® G2-XS Mass Spectrometer, yielding a single integrated platform. The iKey™ is a microfluidic separation device that combines a traditional column, column oven, and electrospray emitter into one, and is integrated into the source of the mass spectrometer.

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