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Extraction of a Drugs of Abuse Panel from Human Urine Using Biotage® Mikro CX SPE Microelution Plates Prior to UPLC-MS/MS Analysis

Introduction

This application note describes the extraction of mulitple drugs of abuse from human urine using Biotage® Mikro CX microelution plates, prior to LC/MS analysis.

The simple sample preparation procedure, based on a mixedmode/strong cation exchange extraction mechanism, delivers clean extracts and analyte recoveries mostly greater than 70% with RSDs lower than 5% for most analytes. Linearity of greater than 0.999 is achieved for all analytes from 1–1000 pg/mL.

Mikro plate extraction allows for very low elution volumes and enhanced workflow efficiency.

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