High-throughput multi-capillary SDS gel electrophoresis of proteins

Introduction
 

Scientists analyzing biotherapeutics are challenged to rapidly and robustly characterize an increasing number and wider variety of drug candidates in less time. Automated capillary electrophoresis instruments offer fast separation times and proven, high reproducibility for capillary sodium dodecyl sulfate gel electrophoresis (SDS-CGE), thus representing an excellent tool for the analysis of therapeutic proteins. However, due to the single capillary format of current systems, the throughput can be limited. The SCIEX BioPhase 8800 system utilized a multi-capillary format that can assist in alleviating this issue, enabling characterization to be performed on multiple samples in parallel.