How chelating agents can easily be analysed using truly inert column hardware!
contributed by YMC |
The separation of certain small molecules can be influenced by the use of stainless steel column hardware. Metal-coordinating compounds such as chelating agents can interact with the metallic surface of the column body, which can adversely affect the analysis. The interaction can lead to loss of recovery, deterioration of peak shapes and sample carry over. The impact is enhanced when new columns are used so that tedious pre-conditioning is necessary.
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