How Fc receptor affinity chromatography correlates with antibody glycosylation and ADCC

Therapeutic antibodies not only specifically bind molecules, but also activate immune responses through interaction of their Fc part with Fc receptors on immune cells. The FcγIIIa receptor is particularly important as it leads to the death of pathogenic cells. The process is referred to as antibody dependent cellular cy totoxicit y (ADCC) and increases with along with affinity to the receptor. This in turn depends on Fc glycosylation.