Hydrogen Deuterium Exchange Coupled with SELECT SERIES Cyclic IMS Mass Spectrometer for Higher Workflow Efficiency

Abstract

Hydrogen deuterium exchange is increasingly employed in the study of larger proteins and protein complexes, and in drug candidate screening applications. These more challenging experiments drive a need for improved performance in the capacity of the LC-MS System. The new SELECT SERIES Cyclic IMS, with higher ion mobility and mass resolution offers improved peak capacity to address these challenges. Here, the performance of the Cyclic IMS System for hydrogen deuterium exchange is demonstrated relative to the SYNAPT G2-Si and SYNAPT XS and for sample limited applications.

^{For research use only. Not for use in diagnostic procedures.}