Molecular Weight Determination of VLPs Using LENS3 Multi-Angle Light Scattering Detector

Viruses and virus like particles (VLPs) are multimeric protein structures that mimic native viruses but are non-infectious. VLPs are subjects of interest, as their potential continues to grow as candidates in new vaccines and gene therapy products. For example, commercially available VLP-based vaccines are available for Hepatitis B and human papillomavirus. Robust analytical techniques are needed to not only ensure quality of final products but provide data for informed decision-making during the development process.