Cookies

Like most websites The Analytical Scientist uses cookies. In order to deliver a personalized, responsive service and to improve the site, we remember and store information about how you use it. Learn more.
Subscribe to Newsletter

Monitoring Structural Changes in Polysaccharides using SEC-MALS

Dextran is one of the most common representatives of polysaccharides, a macromolecule consisting of α-1,6 linkages between glucose units. In addition, α-1,3 (and infrequently α-1,2) linkages can be present, thus creating branches on the main glycan chain (see Figure 1). These materials have a remarkable diversity in physicochemical properties due to the variation in chain length and degree of branching. Dextran’s commercial applications are typically found in the food and pharmaceutical industry, such as vaccines, eye medicines, organ preservation, and blood cell separation. They are also used as blood plasma surrogates.

Pullulan is another widely studied type of polysaccharide. It consists of maltotriose units, made of three glucose monomers with α-1,4 linkages, which are connected by α-1,6 glycosidic bonds (see Figure 2). The coexistence of both types of glycosidic bonds generate an intermediate structure between dextran and amylose. This unique linear structure provides the specific structural flexibility and solubility of pullulan, resulting in distinct film- and fiberforming characteristics which are not exhibited by other polysaccharides. Pullulans have numerous uses in the food, manufacturing, electronic, and pharmaceutical industries, such as wound-healing compositions, pharmaceutical coatings, oral care products, and non-toxic conjugates for vaccines.

Read the full article now

Log in or register to read this article in full and gain access to The Analytical Scientist’s entire content archive. It’s FREE!

Login
Receive content, products, events as well as relevant industry updates from The Analytical Scientist and its sponsors.
Stay up to date with our other newsletters and sponsors information, tailored specifically to the fields you are interested in

When you click “Subscribe” we will email you a link, which you must click to verify the email address above and activate your subscription. If you do not receive this email, please contact us at [email protected].
If you wish to unsubscribe, you can update your preferences at any point.

Register to The Analytical Scientist

Register to access our FREE online portfolio, request the magazine in print and manage your preferences.

You will benefit from:
  • Unlimited access to ALL articles
  • News, interviews & opinions from leading industry experts
  • Receive print (and PDF) copies of The Analytical Scientist magazine

Register