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Optimisation of oligonucleotide separations using YMC´s non porous anion exchanger BioPro IEX QF

Nucleic acid therapeutics such as antisense, siRNA and aptamers are expected to play an important role as the next-generation pharmaceuticals together with antibody drugs. These drugs demand chromatographic purification and analysis that can recognize slight structural differences following synthesis. In this report, useful tips for optimisation of ion exchange chromatography methods for oligonucleotides are provided.

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