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Preparative Purification of Ibuprofen and Related Substances by Nexera UFPLC


Preparation and purification by liquid chromatography is a widely-used technique in the pharmaceutical, food, and chemical industries for drug synthesis, finding effective compounds in natural products, and for structural analysis of unknown trace compounds. Nexera UFPLC*1 enables substantial labor savings in preparative purification by automating not only the fractionation of the target compound but also related processes such as concentration, purification, and recovery. This article describes an example of preparative purification of a mixed sample of the pharmaceutical ibuprofen and its analogues using Nexera UFPLC (Fig. 1).

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