Separation of the ADC Brentuximab vedotin from its aggregates and fragments
contributed by YMC |
Drug-to-antibody ratios (DAR) of antibody-drug-conjugates (ADCs) are important for their therapeutic efficacy and pharmacokinetics. Typically, the DAR of 2nd generation ADC such as Brentuximab vedotin (Adcetris®) is determined by hydrophobic interaction chromatography (HIC).
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