Separation of the ADC Brentuximab vedotin from its aggregates and fragments

contributed by YMC | 04/12/2021

Drug-to-antibody ratios (DAR) of antibody-drug-conjugates (ADCs) are important for their therapeutic efficacy and pharmacokinetics. Typically, the DAR of 2nd generation ADC such as Brentuximab vedotin (Adcetris^®) is determined by hydrophobic interaction chromatography (HIC).

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