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Syft Tracer™: Next Generation Volatile Impurities Analysis


Syft Tracer™ is the latest advancement in selected ion flow tube mass spectrometry (SIFT-MS) technology, delivering even greater stability and reproducibility. For these reasons, together with enhanced sensitivity, this next-generation instrument revolutionizes workflows. This application note describes the benefits that Syft Tracer™ brings to analysis of formaldehyde in a polyethylene glycol (PEG) excipient (Gelucire 44/14). Syft Tracer™ quantifies formaldehyde directly from the polymer headspace without dissolution and eliminates the derivatization step required by chromatographic analyses. Stable quantitation of formaldehyde is demonstrated for almost one month, enabling sample throughputs of over 220 samples/day to be achieved by reducing the calibration frequency. Additionally, Syft Tracer™ is four-fold faster reporting the first result than chromatography-based analyses. 

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