The Acrodisc One™ Syringe Filter Compared to Syringe Filters with Hydrophilic Polypropylene Membrane

Introduction

In many laboratories, the need to consistently generate high-quality data means that laboratory managers and technicians need to ensure their instruments are performing optimally around the clock. Filtering samples before injection into a chromatography instrument is one of the primary ways that an analyst can protect their column and instrument from unnecessary wear and excess downtime. Filtration of both the sample and mobile phase prior to analysis helps increase the lifespan of chromatography columns, reduce overall instrument wear and remove any particles that may interfere with the chromatogram. Sample filtration using syringe filters is a high impact, time effective and easy to implement method.

In the Analytical Technical Guide; Including HPLC and Dissolution Testing, we have shown that particulate removal through filtration can extend column life up to at least 52 times (figure 2) over unfiltered samples. In addition to extending the life of the column, particulate removal also protects the pump, injector, and other components from premature wear.