Using Self-Aware Agilent InfinityLab LC/MSD iQ to Measure Trace-Level Impurities in a Brand Versus Generic Medication

contributed by Agilent Technologies | 01/22/2020

Abstract

This study presents a method for comparison of related impurities in a brand and a generic over-the-counter (OTC) acetaminophen drug. The workflow comprised an Agilent InfinityLab liquid chromatography/mass selective detector (LC/MSD iQ) and an Agilent 1290 Infinity II LC. The study identified impurities at concentrations lower than can be reliably detected by UV.

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