The optimization and scale-up of high shear granulation
This article explains how an inline probe was used to monitor a granulation at three different scales to confirm that, in each case, the granules produced were the same size, and more importantly produced tablets of identical quality as quantified by hardness.
sponsored by Malvern Panalytical
The first step in producing optimized granules for tableting is the wet granulation itself which produces agglomerates that range from a few hundred microns to several millimeters in diameter. These are typically wet milled prior to drying in a fluidized bed dryer. Subsequent milling of a dried particles produces a closely specified granular feed for the tablet press.