Evaluation of Antibody Drug Conjugates using 3D Tumor Spheroids
Searching for winning antibody-drug conjugate (ADC) combinations? Antibody-drug conjugates are entities which combine highly specific monoclonal antibodies (mAbs) and cytotoxic chemotherapeutic drugs. This type of combination provides a highly targeted and powerful therapeutic for the treatment of several types of cancer.
There is a need for robust and reliable techniques for assessing novel candidate drugs. Many researchers now use 3D advanced cell models, such as spheroids or organoids, to assess in vitro drug effects.
Phenotypic and Functional Characterization of CAR-T Cells with High-Throughput Screening by Cytometry and Live-Cell Analysis
Data examples shared in this whitepaper demonstrate how the use of both live-cell analysis and HTS by Cytometry can add value when developing and characterizing T cell therapies.
DownloadEvaluating Antibody Drug Conjugates (ADCs) In Vitro Using 3D Tumor Spheroid Models
A combined workflow approach of iQue® High-Throughput Screening (HTS) by Cytometry and Incucyte® Live-Cell Analysis, for quantifying the function of two ADCs. The iQue® HTS Platform measured target cell counts and viability after spheroid dissociation, enabling profiling of different populations within a co-culture, to reveal differences in spheroid composition.
DownloadiQue® 3 High-Throughput Screening (HTS) by Cytometry
The iQue® 3 HTS Cytometer is designed for high-throughput screening workflows. With a focus on speed and ease of use, it delivers high quality results in the time it takes to enjoy a coffee break. Featuring a patented sampling method, enables continuous plate loading through integration with any automation system.
DownloadiQue® 5 Truly Fast. Simply Effortless.
High-Throughput Screening (HTS) by Cytometry, recognized for effortless operation to empower every user. Provides our most powerful screening capabilities for modern applications, complete with enhanced software features and simplified extended operation for maximum data generation.
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