Extraordinary discoveries demand extraordinary proof
Achieve confident quantitation of low-abundance biomarkers, deeper drug metabolite profiling, and high-precision metabolomics and lipidomics with the ZenoTOF 8600 system.
To drive new discoveries and prove biological significance, you need technology that can outperform what you currently have. You need technology that unlocks new approaches that were previously impossible. You need quantitative data of the highest quality - data that you can stake your reputation on. Discover how the SCIEX ZenoTOF 8600 system can help elevate your research, providing the robust data you need to drive new discoveries and prove biological significance.
White paper: Maximizing analytical output from sensitivity on the ZenoTOF 8600 system
This white paper outlines the technological advancements that enable exceptional sensitivity, robust quantitation, and versatile performance across a wide range of workflows on the SCIEX ZenoTOF 8600 accurate mass system.
DownloadBrochure: SCIEX ZenoTOF 8600 system
Discover the ZenoTOF 8600 system. Do more with a single system, from high-sensitivity targeted quantitation to untargeted approaches that yield more comprehensive discovery datasets.
DownloadApplication note: Quantitative and qualitative bile acid analysis on the ZenoTOF 8600 system using EAD
This application note demonstrates the use of the ZenoTOF 8600 system to quantify the bile acid content in human plasma sample extracts, employing both CID- and EAD-based fragmentation methods. EAD-based fragmentation was strategically used when isomeric pairs overlapped to provide specificity and enable faster analysis times.
DownloadApplication note: Improved lipid identification using the ZenoTOF 8600 system for untargeted lipidomics analysis
Untargeted lipidomics workflows aim to identify as many lipids as possible in a sample. Here, data-dependent acquisition (DDA) experimental data acquired by the ZenoTOF 8600 system were processed using MSDIAL 5.5 software to detect and identify lipid molecular species in human plasma samples.
DownloadApplication note: Breaking the limits: An ultra-sensitive complementary fragmentation for the confident identification and characterization of drug metabolites
This application note demonstrates an ultra-sensitive method for confidently identifying and structurally elucidating drug metabolites, leveraging the enhanced MS1 and electron-activated dissociation (EAD) MS/MS sensitivity of the ZenoTOF 8600 system.
DownloadApplication note: Advances in high-throughput quantitative proteomics powered by high-sensitivity data-independent acquisition on the ZenoTOF 8600 system
This application note describes high-throughput quantitative proteomics using the ZenoTOF 8600 system. Combining improved separations and high-sensitivity data-independent acquisition (DIA), as many as 26,000 precursors and 4,000 protein groups were identified from a 5 ng commercial human digest at a 500 samples-per-day (SPD) throughput.
DownloadApplication note: Achieving deep quantitative proteome coverage from sub-nanogram sample loadings using Whisper Zoom and Zeno SWATH DIA on the ZenoTOF 8600 system
This application note presents a quantitative proteomics workflow for low sample volumes. Leveraging highly sensitive data-independent acquisition (DIA), the method enables the identification of more than 4,900 protein groups and over 35,000 precursors from 250 pg of a commercial human digest using nanoflow separations at a throughput of 40 samples per day (SPD).
DownloadApplication note: Improved metabolite identification using the ZenoTOF 8600 system to analyze NIST SRM 1950 plasma by DDA analysis
Here, human plasma was analyzed using the ZenoTOF 7600 and 8600 instruments to evaluate the improved identification of analytes in untargeted metabolomics analysis on human plasma using reversed-phase (RP) chromatography.
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