YOUR LC-MS WORKFLOW. SIMPLIFIED.

Avantor® Offers Versatile Sample Prep, Solvents and Columns for LC-MS Workflows

Managing LC-MS operations comes with its share of challenges — whether it’s ensuring reproducible results, developing or optimizing methods, keeping up with regulations or managing supply chain complexities. We understand these hurdles and provide solutions to help you succeed.

Avantor’s resources provided here are tools designed to streamline your application search and boost lab productivity. It offers actionable insights and resources for:

  • Lab managers: Discover HPLC and LC-MS methods tailored to evolving demands and the latest LC and LC-MS applications.

  • LC-MS scientists: Access detailed chromatographic performance data, example chromatograms and step-by-step guidance to stay efficient and informed.

  • Procurement teams: Find reliable product information, maximize product value and ensure on-time delivery to keep your team moving forward.

Chromatography White Paper

The document highlights the development and application of highly sensitive analytical techniques, specifically Liquid Chromatography-Mass Spectrometry (LC-MS/MS), for the determination of eight key nitrosamines (NDMA, NDEA, NMBA, NEIPA, NDIPA, NMPA, NDPA, and NDBA). It details a method using an Avantor ACE UltraCore C18 column for separating these compounds from the active pharmaceutical ingredient (API), achieving low ppb detection limits.

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ACE Catalogue

The Avantor® ACE® HPLC and UHPLC columns product catalogue details a wide range of chromatography solutions, including 20 phases, 7 particle sizes, and various column lengths and IDs. It highlights the superior peak shape, excellent lifetimes under extreme pH conditions, and high efficiencies of ACE columns compared to other brands. The catalogue also introduces novel chemistries, UHPLC columns, columns for biomolecules, HILIC phases, and method development kits.

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Application Note: MS-friendly Method for Oligonucleotide Separation

This application note details an MS-friendly method for oligonucleotide separation using an Avantor® ACE® Excel 1.7 Oligo column. The method outlines specific mobile phases, a gradient program, and system parameters including flow rate, injection volume, temperature, and UV detection. An ordering table provides product details and part numbers for the column and all reagents used.

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Success Story

Avantor® helped a pharmaceutical company's scientists focus on innovation by taking over routine small molecule purification tasks. This "Science as a Service" program returned 7,209 direct resource hours to scientists in nine months and improved purification efficiency by 20%. The success led to expanding Avantor's services to other scientific areas within the company.

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Technical Note: Column Selection for Peptide and Protein RPLC Separations in Biopharma Analysis

This technical note guides column selection for peptide and protein RPLC separations in biopharmaceutical analysis. It discusses particle characteristics (fully porous vs. solid core, size), silica purity, pore diameter (100 Å for peptides, >300 Å for proteins), and stationary phase chemistry (C18 for peptides, C4/phenyl for proteins). It also covers column length and internal diameter for optimal resolution and sensitivity.

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LC-MS Solutions Guide

Avantor offers comprehensive LC-MS solutions, including high-purity solvents (J.T.Baker®), columns (ACE®, HiChrom®), and sample preparation products like syringe filters and SPE. They provide expert technical support, customization, and a reliable supply chain, aiming to simplify LC-MS workflows for various applications like biopharma and research, ensuring consistent and reproducible results.

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