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Fields & Applications Pharma & Biopharma

Determination of phthalates in water using the VWR-Hitachi ChromasterUltra Rs new high-resolution column

sponsored by VWR

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Phthalates are present in a vast range of consumer products owing to their use as plasticisers, dispersants, gelling agents and emulsifying agents to name but a few.

They are known, however, to cause malformations of the reproductive tract in mammals  and there is also reported genotoxicity in humans.   It is therefore important to monitor these within consumer products.  This causes some problems for the Chromatographer as separation of such compounds using RP HPLC can be troublesome in that full base line separation is not achieved between a number of peaks. Therefore, some methods are developed with needlessly complicated gradients, which, of course, reduce the robustness of the method.

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