Researchers from the University of Zurich got a close encounter of the spectroscopic kind when they looked at the interaction between protein histone H1 and its binding partner, prothymosin α. Using single-molecule fluorescence and nuclear magnetic resonance spectroscopy, the team discovered that there is a strong electrostatic attraction between the two proteins, and that they have extended unstructured protein chains – a finding that could have implications for future drug development.
Credit: Christoph Schumacher, dunkelweiss
Reference: A Borgia et al., “Extreme disorder in an ultrahigh-affinity protein complex”, Nature, 555, 61–66 (2018).
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