Davy Guillarme

Meet Davy Guillarme

Main research aims? My research focuses on developing advanced liquid chromatography and mass spectrometry methods to analyze and characterize new drug modalities, including mAbs, oligonucleotides, and cell and gene therapy products.

Most exciting development or emerging trend… The most exciting development in analytical science today is the integration of advanced technologies such as ultra-high performance liquid chromatography, high-resolution mass spectrometry, artificial intelligence, and machine learning to enhance the performance and predictive capabilities of analytical methods.

Missing from the analytical toolbox? A mass spectrometry-based detector capable of providing high sensitivity for analyzing very large molecules, such as mAbs, mRNA, and AAVs, would be highly valuable. While ESI-MS performs reasonably well for such large molecules, its sensitivity is often insufficient. The development of a new or revolutionary ionization mode and/or mass analyzer specifically designed for very large molecules would be greatly welcomed.