Analyzing polar compounds using liquid chromatography has historically been a challenge. Poor retention and peak shape, complex mobile phases that may not be MS-friendly, long equilibration times, low sensitivity, and sample derivatization are all complications that reduce lab efficiency and productivity. However, new Raptor Polar X columns reliably retain and efficiently separate a broad range of polar analytes using a unique stationary phase that balances two retention mechanisms: HILIC and ion exchange. This hybrid phase is ideal for analyzing acidic, basic, and neutral polar compounds without time-consuming derivatization or complex ion pairing, and it is especially compatible with mass spectrometry.
