Kromasil presents a new wettable C18 phase specifically engineered for biomolecules and API purification and manufacturing. Based on porous spherical 100 Å silica, Kromasil C18(w) can be loaded and run under 100% aqueous conditions. Under those conditions, stopping the flow (followed by pressure drop) through the column, on a regular, fully hydrophobic, C18 phase would normally results in phase dewetting and collapse with a dramatic loss of interaction surface and separation capacity. In contrast, Kromasil C18(w) do remain fully wetted in such circumstances, keeping full contact between mobile and stationary phase, and excellent efficiency. Learn more on the Kromasil website.
